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MADRID, Aug. 31, 2021 /PRNewswire/ -- Results from a new human clinical study demonstrate a significant capacity for Pharmactive's potent all-natural affron® standardized saffron extract to promote restorative sleep. The ingredient showed its effect in a single, low dose taken just one hour before bedtime, making affron a natural ingredient that is very easy to consume. Moreover, the results are the first to suggest a novel mechanism of action for affron on melatonin levels helping to elevate the natural production of melatonin in the body before bedtime. This opens a new possible mechanism of action for affron openly related to sleep, besides its well-known effects on neurotransmitters balance, and its antioxidant and anti-inflammatory properties.